Steve Jean
Directeur de département, Faculté de médecine et des sciences de la santé
FMSS Dép. d'immunologie et de biologie cellulaire
Présentation
Sujet de recherche
Cell Signaling, Molecular Genetics, Cell Signaling and Cancer, Genetic Diseases
Disciplines de recherche
Cell Biology, Genetics
Mots-clés
Autophagy, Cellular biology, Drosophila melanogaster, Endocytosis, Functional Genomic, Live cell imaging, Membrane Trafficking, Phosphoinositides, Proteomics, RAB GTPases
Centre de recherche
Centre de recherche du CHUS
Langues parlées et écrites
Anglais, Français
Diplômes
(2021). (Certificate, EMBO Laboratory Leadership class).
(2015). (Post-doctorate, Postdoctoral fellow). University of California, San Diego.
(2008). Characterization of novel partners for the kinases xPAK1 and xMLK2 during early Xenopus laevis development (Doctorate, Doctorate in Molecular and Cellular Biology). Université Laval.
(2003). Identification of novel partners for the kinases xPAK1 and xMLK2 during early Xenopus laevis development (Master's non-Thesis, Master in Molecular and Cellular Biology - Masters). Université Laval.
(2001). (Bachelor's, Microbiology). Université Laval.
Expérience académique
Professor. (2024-). Université de Sherbrooke. Canada.
Cell Biology Program Director. (2021-). Université de Sherbrooke. Canada.
Associate Professor. (2019-2023). Université de Sherbrooke. Canada.
Prix et distinctions
- (2027) FRQS, Chercheur Senior salary award. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
- (2023) FRQS, Chercheur Boursier Junior 2. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
- (2021) Dean's list of exceptional professoral award. Université de Sherbrooke. (Prize / Award).
- (2020) CIHR New Investigator Salary Award : 2014-2015 competition. Canadian Institutes of Health Research. (Prize / Award).
- (2019) FRQS, Chercheur Boursier Junior 1 - Declined. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
- (2018) Dean's list for exceptional professoral performance. Université de Sherbrooke. (Prize / Award).
- (2018) Dean's list for exceptional professoral performance (2 years). Université de Sherbrooke. (Prize / Award).
- (2015) American Heart Association Post-doctoral Fellowship - Declined. American Heart Association. (Prize / Award).
- (2015) Scholarship for the Next Generation of Scientists. Cancer Research Society. (Prize / Award).
- (2012) FRQS Postdoctoral fellowship. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
- (2009) Honors Board for Ph.D. thesis. Université Laval. (Distinction).
- Best Oral Presentation. Journée de la Faculté de médecine. (Prize / Award).
- Best Poster Presentation. Congrès Signalisation Québec. (Prize / Award).
- Best Poster Presentation. International Meeting on Cytoskeleton Dynamics. (Prize / Award).
- Corresponding author publication recommended by F1000. Faculty of 1000. (Citation).
- Genome Publication Award and Molecular Biology of the Cell (MBoC) editor's highlighted manuscript. ASCB-MBoC journal. (Distinction).
- Highest academic average of microbiology promotion 2001. Université Laval. (Distinction).
- Outstanding Reviewer Award. Canadian Institutes of Health Research. (Prize / Award).
- Poster Award (First Jury Prize) Lab Oratoire. Laval University Graduate Student Association (AELIES). (Prize / Award).
- Poster Award (Public Prize) Lab Oratoire. Laval University Graduate Student Association (AELIES). (Prize / Award).
- Poster Presentation Award. Cancer Research Center Student's Scientific Day. (Prize / Award).
- Scientific president of the 2021 regional Expo-Sciences final. Expo-sciences. (Distinction).
- Travel Award. Cold Spring Harbor Laboratory. (Prize / Award).
- Travel Award. CIHR National Poster Competition. (Prize / Award).
- Travel Award. 11th International Xenopus Meeting. (Prize / Award).
- Travel Award. Université Laval. (Prize / Award).
- Travel Award. Université Laval. (Prize / Award).
- Travel Award. Université Laval. (Prize / Award).
- Travel Award. 10th International Xenopus meeting. (Prize / Award).
- Travel Award. Gordon Research Conference. (Prize / Award).
Financement
- Grant. (Awarded). Principal Applicant. Interplay between RAB21 and endosomal sorting machinery. Canadian Institutes of Health Research (CIHR). Project Grant. 975 000 $. (2024-2029)
- Grant. (Awarded). Principal Applicant. Membrane trafficking regulation by inter-organelle contact sites. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery grants. 200 000 $. (2023-2028)
- Grant. (Under Review). Co-investigator. Évolution des G-Quadruplets dans la régulation de l'autophagie. Fonds Québécois de la Recherche sur la Nature et les Technologies (FQRNT). Team grant. 150 000 $. (2024-2027)
- Grant. (Awarded). Co-applicant. Journey to the Center of the Cell: Reprogramming intracellular transport to the nucleus enhances HER2+ tumor killing for trastuzumab conjugated to payloads active in the nucleus. Canadian Institutes of Health Research (CIHR). Project grant. 750 000 $. (2021-2026)
- Grant. (Under Review). Principal Applicant. Interplay between RAB21 and endosomal sorting machinery. Canadian Institutes of Health Research (CIHR). Project grants. 1 250 000 $. (2020-2025)
- Grant. (Awarded). Principal Applicant. In vivo roles of autophagy in gut homeostasis and impact on IBD. Canadian Institutes of Health Research (CIHR). 2020 Project Grant Competition. 895 000 $. (2020-2025)
- Grant. (Awarded). Principal Applicant. Development of a Drosophila TTC7A deficiency model for genetic interaction studies. Rare Disease Foundation (The). RDMM/FGPDL Open Call competition. 30 000 $. (2023-2024)
- Grant. (Awarded). Principal Applicant. Congrès Signalisation Québec. Canadian Institutes of Health Research (CIHR). Dissemination grant. 10 000 $. (2024-2024)
- Grant. (Completed). Co-applicant. 2023 Canadian Drosophila Conference. Canadian Institutes of Health Research (CIHR). Dissemination grant. 10 000 $. (2023)
- Grant. (Completed). Principal Investigator. Coordination of phosphoinositides and RAB GTPases in membrane trafficking events. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery Grants. 252 000 $. (2016-2023)
- Research Chair. (Completed). Principal Investigator. Endosomal regulation of autophagy in intestinal diseases. Centre de Recherche Médicale de l'UdeS. Junior Faculty Research Chair. 240 000 $. (2018-2023)
- Grant. (Completed). Principal Applicant. Journée Phare 2019. Canadian Institutes of Health Research (CIHR). Dissemination grant. 8 000 $. (2019)
- Grant. (Completed). Co-applicant. Chronic Inflammation, Immunity and Cancer 2019. Canadian Institutes of Health Research (CIHR). Dissemination grant. 15 000 $. (2019)
- Grant. (Completed). Principal Applicant. Signalling functions in cancer for a RAB GTPase. Cancer Research Society (The). Operating Grants. 120 000 $. (2017-2019)
- Grant. (Completed). Co-investigator. Harnessing CRISPR/Cas9 technology for fundamental and translational cancer studies. Centre Recherche en Inflammation et Oncologie Digestive de l'Université de Sherbrooke (CRIODUS). Structuring grant. 18 000 $. (2018-2019)
- Grant. (Completed). Principal Investigator. In vivo studies of autophagy: from the model organism to human organoids. Canada Foundation for Innovation (CFI). John R Evans Leaders Fund. 952 000 $. (2017-2018)
- Grant. (Completed). Principal Applicant. Développement d’un nouveau modèle de cancer colorectal chez la drosophile: étude de l’efficacité thérapeutique de l’autophagie et effet du statut de p53 dans ce modèle.. CRIODUS. Structuring grant. 15 000 $. (2016-2017)
Publications
Articles de revue
- Gaudeault St-Laurent V*, Marchand B.*, Larcher R.*, Nassari S*, Bourassa F, Moreau M*, Jean D*, Boisvert FM.,Brunet MA. and Jean S. (2024). A proximity map of small GTPases. Communications biology N/A N/A. (Submitted).
- Lacarrière-Keïta, C*, Nassari S* and Jean S. (2024). Autophagy inhibition in intestinal stem cells favors enteroendocrine cell differentiation through Stat92E activity. Disease Models & Mechanisms N/A N/A. (Submitted).
- Mancuso C., Tremblay E., Gnodi E., Jean S., Beaulieu JF. and Barisani. D. (2023). The combination of gold and silver food nanoparticles with gluten peptides alters the autophagic pathway in intestinal crypt-like cells. International Journal of Molecular Science 24 (17), 13040. (Published).
- Maruzs T., Feil-Borcsok D., Lakatos E., Juhasz G., Hargitai D., Jean S., Lorincz P. and Juhasz G. (2023). The sorting next 25 homolog Snazarus counteracts Rab11 to balance secretory and endocytic transport and maintain the ultrafiltration diaphragm in nephrocytes. Molecular Biology of the Cell 34 (9), ar87. (Published).
- *Lacarrière-Keïta C., *Nassari S. and Jean S. (2022). Autophagy in cell fate decisions: Knowledge gained from Drosophila. Genome 65 (12), 573-584. (Published).
- Marchand B., Poulin MA., Lawson C., Tai LH., Jean S. and Boucher MJ. (2022). Gemcitabine promotes autophagy and lysosomal function through Erk- and TFEB-dependent mechanisms. Cell Death Discovery 9 :45. (Published).
- *Nassari S., *Lacarrière-Keïta C., Lévesque D., Boisvert FM. and Jean S. (2022). Rab21 in enterocytes participates in intestinal epithelium maintenance. Molecular Biology of the Cell 33:ar32 1-21. (Published).
- Jean S. and *Nassari, S. (2022). Regulation of Endosomal Sorting and Maturation by ER-Endosome Contact Sites. Contact - Supported by NSERC June (5), 1-9. (Published).
- *Lauzier A. and Jean S. (2022). Snazarus/SNX25 at the crossroad of endocytosis and lipid handling in autophagy. Autophagy Reports 1 42-46. (Published).
- *Lauzier A., *Bossanyi M.F., * Larcher R., *Nassari S., Ugrankar R., Henne MW. and Jean S. (2022). Snazarus and its human ortholog SNX25 modulate autophagic flux. Journal of Cell Science 135 (5), N/A. (Published).
- Klionsky DJ et al. including Steve Jean. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17 (1), 1-382. (Published).
- Brunet, MA., Jacques JF., *Nassari S., Tyzack GE, McGoldrick P., Zinman L., Jean S., Robertson J., Patani R., Roucou X. (2021). The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity. EMBO Reports 22 -. (Published).
- Lacasse, V., Beaudoin S., Jean S. and Leyton JV. (2020). A novel and generalizable proteomic method reveals classical NLS-tagging of trastuzumab-emtansine contravenes classical nuclear transport in a model of HER2-positive breast cancer. Molecular Therapy Methods & Clinical Development 19 99-119. (Published).
- *Nassari., S, *Del Olmo, T., Jean S. (2020). Rabs in Signaling and Embryonic Development. International Journal of Molecular Sciences 21 (3), 1064. (Published).
- *Del Olmo T, *Lauzier A, *Normandin C, *Larcher R, *Lecours M, *Jean D, *Lessard L, Steinberg F, Boisvert FM and Jean S. (2019). APEX2-mediated RAB proximity labeling identifies a RAB21 role in clathrin-independent cargo sorting. EMBO Reports 20 (2), 1-21. (Published).
- *Lauzier A, *Normandeau-Guimond J, Vaillancourt-Lavigueur V, Boivin V, Charbonneau M, Rivard N, Scott MS, Dubois CM, Jean S. (2019). Colorectal cancer cells respond differentially to autophagy inhibition in vivo. Scientific Reports 9 11316. (Published).
- Ugrankar R, Bowerman J, Hariri H, Chandra M, Chen K, *Bossanyi MF, Datta S, Rogers S, Eckert KM, Vale G., Victoria A, Fresquez J, McDonald JG, Jean S, Collins BM and Henne MW. (2019). Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes. Developmental Cell 50 557-572. (Published).
- Binda C, Génier S, Picard S, Degrandmaison J, Fréchette L, Jean S, Marsault E, Parent JL. (2019). L-type prostaglandin D synthase regulates the trafficking of the PGD2 DP1 receptor through an interaction with Rab4. Journal of Biological Chemistry 8 16865-16883. (Published).
- *Del Olmo T, *Lacarrière-Keïta C, *Normandin C, *Jean D, Boisvert FM, Jean S. (2019). RAB21 interacts with TMED10 and modulates its localization and abundance. Biology Open 9 bio045336. (Published).
- Paquette M, Beaudoin S, Tremblay MA, Jean S, Lopez A, Lecomte R, Guérin B, Bentourkia M, Sabbagh R, Leyton J. (2018). NLS-cholic acid conjugation to IL-5R-specific antibody improves cellular accumulation and in vivo tumor-targeting properties in a bladder cancer model. Bioconjugate Chemistry 18 1352-1363. (Published).
- Fujita N, Haung W, Lin TH, Groulx JF, Jean S, Nguyen J, Kuchitsu Y, Koyama-Honda I, Mizushima N, Fukuda M and Kiger AA. (2017). Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy. eLife 6 (e23367), 10.7554. (Published).
- Jean S and Kiger AA. (2016). Rab21 activity measurement using GST-fused APPL1. Bio-Protocol 6 (4), e1739. (Published).
- Jean S and Kiger AA. (2016). VAMP8-3xHA uptake assays in HeLa cells. Bio-Protocol 6 (4), e1738. (Published).
- Jean S, Cox S, Nassari S* and Kiger AA. (2015). Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 trafficking to promote autophagosome-lysosome fusion. EMBO Reports 16 (3), 297-311. (Published).
- Jean S and Kiger AA. (2014). Classes of phosphoinositide 3-kinases at a glance. Journal of Cell Science 127 (5), 923-928. (Published).
- Jean S and Kiger AA. (2012). Coordination between RAB GTPase and phosphoinositide regulation and functions. Nature Reviews Molecular Cell Biology 13 (7), 463-470. (Published).
- Jean S, Cox S, Schmidt EJ, Robinson FL and Kiger AA. (2012). Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. Molecular Biology of the Cell 23 (14), 2723-2740. (Published).
- Jean S, Tremblay MG, Herdman C, Guillou F and Moss T. (2012). The endocytic adapter E-Syt2 recruits the p21 GTPase activated kinase PAK1 to mediate actin dynamics and FGF signalling. Biology Open 1 (8), 731-738. (Published).
- Michaela Velichkova, Joe Juan, Pavan Kadandale, Steve Jean, Inês Ribeiro, Vignesh Raman, Chris Stefan and Amy Kiger. (2010). Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions. Journal of Cell Biology 190 (3), 407-425. (Published).
- Steve Jean, Alexander Mikryukov, MIchel G Tremblay, Jöelle Baril, François Guillou, Sabrina Bellenfant and Tom Moss. (2010). Extended-Synaptotagmin-2 Mediates FGF Receptor Endocytosis and ERK Activation In Vivo. Developmental Cell 19 (3), 426-39. (Published).
- Steve Jean and Tom Moss. (2008). A ubiquitin-conjugating enzyme, ube2d3.2, regulates xMLK2 and pronephros formation in Xenopus. Differentiation 76 (4), 431-441. (Published).
- Luc Poitras, Steve Jean, Nazrul Islam and Tom Moss. (2003). PAK interacts with NCK and MLK2 to regulate the activation of jun N-terminal kinase. FEBS Letters 543 (1-3), 129-135. (Published).
- Nicolas Bisson, Nazrul Islam, Luc Poitras, Steve Jean, Anne Bresnick, Tom Moss. (2003). The catalytic domain of xPAK1 is sufficient to induce myosin II dependent in vivo cell fragmentation independently of other apoptotic events. Developmental Biology 263 (2), 264-281. (Published).
Chapitres de livre
- *Lauzier A. and Jean S. (2018). Autophagic flux assessment in colorectal cancer cells. Jean-François Beaulieu. Methods in molecular biology - Colorectal cancer (167-175). United States of America : Springer. (Published).
Articles de conférence
- Jean S., Gaudreault V*., Larcher R*., Marchand B*. (2023). A proximity interaction map of RAB GTPases. Cell Bio 2023 - American Society of Cell Biology. (Accepted).
- *Nassari S. and Jean S. (2022). An unexpected contribution of Rab21 in mitochondria size. Cell Symposia – Multifaceted mitochondria. (Accepted).
- Jean S., *Larcher R. and *Marchand B. (2022). A proximity interaction map of RAB GTPases. FASEB – Small GTPases in membrane processes. (Published).
- *Nassari S., *Lacarrière-Keita C., Lévesque D., Boisvert FM. and Jean S. (2022). Early endosomal Rab21 in enterocytes contributes to gut tissue maintenance. 63rd Annual Drosophila Research Conference. (Published).
- *Lacarrière-Keita C. and Jean S. (2022). Sbf and Rab21 controls autophagic flux to modulate drosophila intestinal stem cell fate. 62nd Annual Drosophila Research Conference. (Published).
- *Lacarrière-Keita C. and Jean S. (2022). Sbf and Rab21 joue un role dans la differentiation intestinale. Signalisation Québec 2022. (Published).
- *Lacarrière C. and Jean S. (2022). Sbf and Rab21 play a new role in drosophila intestinal cell differentiation, most likely through their regulatory functions on autophagy. Gordon Research conference on autophagy. (Published).
- *Nassari S. and Jean S. (2022). Un nouveau role de RAB21 aux mitochondries. Signalisation Québec 2022. (Published).
- *Larcher R., *Marchand B. and Jean S. (2020). A RAB proximity ligation screen identifies novel potential RAB25 interacting proteins. American Society for Cell Biology annual meeting. (Published).
- *Nassari S. and Jean S. (2020). Endosomal-related function of RAB21 in enterocytes participates to intestinal homeostasis via EGFR pathway regulation. American Society for Cell Biology annual meeting. (Published).
- *Bossanyi M. and Jean S. (2020). Rab21 modulates Snazarus localization and impacts lipid droplets biogenesis. FASEB - The Lipid Droplets Conference. (Accepted).
- *Lacarrière-Keita C. and Jean S. (2020). Sbf and Rab21 controls autophagic flux to modulate drosophila intestinal stem cell fate. American Society for Cell Biology annual meeting. (Published).
- *Normandin C. and Jean S. (2019). Drosophila A eye modifier screen identifies potential Rab21 GTPase Activating Proteins. Canadian National Proteomic Network. (Published).
- *Del Olmo T. *Lecours M., *Jean D. Boisvert FM., Jean S. (2019). Early endosomal Rab21 mediates mTOR kinase trafficking. Chronic Inflammation and Cancer 2019. (Published).
- *Nassari S. and Jean S. (2019). Rab21 contributes to enterocytes survival and participates to intestinal renewal in a non-cell autonomous manner. 2019 European Drosophila Research Conference. (Published).
- *Nassari S. and Jean S. (2019). Rab21 in enterocytes participates to the maintenance of the intestinal epithelium. Chronic Inflammation and Cancer 2019. (Published).
- *Lacarrière C. and Jean S. (2019). Sbf and Rab21: two autophagy regulators involved in intestinal cell fate determination. Canadian Digestive Diseases Week (CDDW). (Published).
- *Lacarrière C. and Jean S. (2019). Sbf and Rab21: two autophagy regulators involved in intestinal cell fate determination. Chronic Inflammation and Cancer 2019. (Published).
- *Lacarrière C. and Jean S. (2019). Sbf and Rab21: two autophagy regulators involved in intestinal cell fate determination. XV Canadian Drosophila Conference. (Published).
- *Bossanyi MF., Ugrankar R., Henne MW., Jean S. (2019). Snazarus and modulates lipid droplet biogenesis. XV Canadian Drosophila Conference. (Published).
- *Normandin C. and Jean S. (2019). The GTPase activating protein TBC1D25 modulates multiple Rab21 functions. Chronic Inflammation and Cancer 2019. (Published).
- *Nassari S. and Jean S. (2019). The non-cell autonomous contribution of Rab21 in Drosophila gut renewal. 60th International Drosophila Conference. (Published).
- *Normandin C. and Jean S. (2018). A drosophila eye modifier screen identifies potential GTPase Activating Protein implicated in autophagy. Signalisation Québec 2018. (Published).
- *Normandin C. and Jean S. (2018). A drosophila eye modifier screen identifies potential GTPase Activating Protein implicated in autophagy. Autophagy in Stress, Development and Disease, Gordon Research Conference. (Published).
- *Del Olmo T., *Lecours M., *Lauzier A., *Jean D., Boisvert FM., Jean S. (2018). Dynamic APEX2-mediated Rab proximity labeling identifies a Rab21 role in mTOR signaling. FASEB : Small GTPases in membrane processes: Trafficking, Autophagy and Disease. (Published).
- *Bossanyi MF., Boucher MJ., Jean S. (2018). Implication de Snazarus et de Rab21 dans la formation de gouttelettes lipidiques. Club de Recherche Clinique du Québec. (Published).
- *Bossanyi MF., Boucher MJ., Jean S. (2018). Implication de Snazarus et de Rab21 dans la formation de gouttelettes lipidiques. Signalisation Québec 2018. (Published).
- *Del Olmo T., *Lauzier A., *Jean D., Boisvert FM., Jean S. (2018). Interactome de Rab21 généré par ligation de proximité identifie un nouveau rôle pour Rab21 avec le complexe WASH. Signalisation Québec 2018. (Published).
- *Nassari S. and Jean S. (2018). Rôle de Rab21 dans l’homéostasie intestinal chez la drosophile. Signalisation Québec 2018. (Published).
- *Normandin C. and Jean S. (2018). TBC1D25 dans la régulation négative de Rab21, une protéine impliquée dans divers processus tumoraux. Club de Recherche Clinique du Québec. (Published).
- *Lauzier A. and Jean S. (2018). Targeting autophagy in colorectal cancer: a relevant strategy?. Autophagy in Stress, Development and Disease, Gordon Research Conference. (Published).
- *Del Olmo T., *Jean D., Boisvert FM., Jean S. (2017). Definition of the Rab21 interactome through complementary quantitative mass spectrometry approaches. Société canadienne pour les Biosciences moléculaires 2017. (Published).
- *Lacarrière C. and Jean S. (2017). Rôle et régulation de la pseudophosphatase MTMR13/SBF dans l’homéostasie intestinale. Journée Phare. (Published).
- *Normandin C. and Jean S. (2017). TBC1D25 une GAP potentielle de Rab21. Journée Phare 2017. (Published).
- Jean S and *Lauzier A. (2017). The sorting nexin Snazarus regulates autophagosome-lysosome fusion. 58th International Drosophila Conference. (Published).
- *Normandeau-Guimond J. and Jean S. (2016). Analyse du flux autophagique de cellules cancéreuses colorectales. Signalisation Québec 2016. (Published).
- *Normandin C. and Jean S. (2016). Identification et caractérisation de GAPs spécifiques à Rab21. Journée Phare 2016. (Published).
- *Normandin C. and Jean S. (2016). Identification et caractérisation de GAPs spécifiques à Rab21. Signalisation Québec 2016. (Published).
- *Normandin C. and Jean S. (2016). Identification et caractérisation de GAPs spécifiques à Rab21. Club de Recherche Clinique du Québec. (Published).
- *Del Olmo T. and Jean S. (2016). Interactome fonctionnel de Rab21 et son rôle dans la tumorigenèse. Signalisation Québec 2016. (Published).
- *Del Olmo T. and Jean S. (2016). Le protéome de Rab21 et son rôle dans le cancer. Journée Phare 2016. (Published).
- *Del Olmo T. and Jean S. (2016). Le protéome de Rab21 et son rôle dans le cancer. Club de Recherche Clinique du Québec. (Published).
- Jean S. (2016). Regulation of gut homeostasis by membrane trafficking proteins. Canadian Digestive Diseases Week (CDDW). (Published).
- Jean S., Cox S., Kiger A. (2015). Rab21 and Sbf regulate autophagosome-lysosome fusion. CanFly XIII 2015. (Published).
- Jean S., Cox S., Kiger A. (2014). Starvation-induced MTMR13 and Rab21 activity promotes VAMP8 autophagosome-lysosome fusion. 2014 Annual drosophila research conference. (Published).
Autres contributions
Présentations
- Jean S. (2023). Definition of RAB interactors through proximity labelling. 12th Signalling in Normal and Cancer Cells Conference. Banff, Canada
- Jean S. (2023). Early endosomal regulation of Signaling in tissue homeostasis. PROTEO seminar serie. Virtual, Canada
- Jean S. (2022). An unexpected role of RAB21 at mitochondria. Signalisation Québec 2022. Bécancour, Canada
- Jean S. (2022). A proximity interaction map of RAB GTPases. FASEB – Small GTPases in membrane processes. Halifax, Canada
- Jean S. (2022). Autophagy in intestinal functions. McGill University, Molecular sciences seminar series. Montreal, Canada
- *Lacarrière-Keita C. and Jean S. (2022). Sbf and Rab21 play a new role in drosophila intestinal cell differentiation, most likely through their regulatory functions on autophagy. Gordon Research Seminar autophagy meeting. Ventura, United States of America
- *Nassari S. and Jean S. (2021). An unexpected contribution of Rab21 in mitochondrial dynamics. Canadian Drosophila Conference. Virtual conference, Canada
- Jean S. (2021). Endosomal regulation of signaling and tissue homeostasis. University of Calgary seminar series. Calgary, Canada
- Jean S. (2021). Régulation endosomale de la signalisation intracellulaire. Club de Recherches Cliniques du Québec. Online, Canada
- *Lacarrière-Keita C. and Jean S. (2021). Sbf and Rab21 play a new role in drosophila intestinal cell differentiation, most likely through their regulatory functions on autophagy. Canadian Drosophila Conference. Virtual conference, Canada
- *Lacarrière-Keita C. and Jean S. (2021). Sbf et Rab21, deux régulateurs de l’autophagie, impliqués dans la détermination de la cellule souche intestinale. 88e congrès de l’ACFAS. Sherbrooke, Canada
- *Lacarrière-Keita C. and Jean S. (2020). Sbf and Rab21, two autophagy regulators involved in intestinal cell differentiation. Flying through the gut seminar virtual international series. Vitrual, Canada
- *Nassari S. and Jean S. (2020). The contribution of membrane trafficking in enterocytes survival. Flying through the gut seminar virtual international series. Virtual symposia, Canada
- *Nassari S. and Jean S. (2019). Autophagy contributes to enterocytes survival and participates to intestinal renewal in a cell non-autonomous manner. Journée Phare. Orford, Canada
- Jean S. and *Nassari S. (2019). Endosomal and autophagic regulation of intestinal homeostasis. Chronic Inflammation, Immunity and Cancer. Orford, Canada
- *Lacarrière C. and Jean S. (2019). Sbf and Rab21: two autophagy regulators involved in intestinal cell fate determination. Canadian Digestive Diseases Week (CDDW). Banff, Canada
- Jean S. (2018). APEX2-mediated proximity labelling of RAB GTPases identify a role for RAB21 in clathrin independent endocytosis. Signaling in Normal and Cancer Cells. Banff, Canada
- *Del Olmo T., *Lecours M., *Lauzier A., *Jean D., Boisvert FM and Jean S. (2018). Dynamic APEX2 as a tool to define Rabs functions. FASEB - Small GTPases in membrane processes: Trafficking, Autophagy and Disease. Leesburg, United States of America
- Jean S. (2018). Proteomic and Genetic Approaches to Decipher RAB functions. Hôtel-Dieu de Québec Seminar Series. Québec, Canada
- Jean S. (2018). Proteomic and Genetic Approaches to Decipher RAB functions. Sick Kids Seminar Series. Toronto, Canada
- Jean S. (2018). Proteomic and Genetic Approaches to understand RAB GTPases roles. Département de Biochimie – Université de Montréal Seminar Series. Montreal, Canada
- *Lacarrière C. and Jean S. (2018). Role de la myotubularine MTMR13, une protéine régulant l’autophagie, dans le renouvellement de l’épithélium intestinal. Signalisation Québec 2018. Bécancour, Canada
- Jean S. (2018). Targeting autophagy in colorectal cancer cells: a relevant strategy?. Discovery on Target 2018 – Autophagy Workshop. Boston, United States of America
- *Del Olmo T., *Jean D. Boisvert FM., Jean S. (2017). Caractérisation de l’interactome fonctionnel de Rab21 et rôle dans la tumorigénèse. Club de Recherche Clinique du Québec. Orford, Canada
- *Del Olmo T., *Jean D., Boisvert FM. and Jean S. (2017). Caractérisation de l’interactome fonctionnel de Rab21 et rôle dans la tumorigénèse. 86e congrès de l’ACFAS. Montreal, Canada
- Jean S. (2017). Endosomal regulation of autophagy. Canadian Drosophila Research Conference XIV. Banff, Canada
- Jean, S. (2017). Inhiber l’autophagie dans le cancer : un pensez-y-bien!. Cancer and inflammation research axis retreat. Canada
- Jean S. (2017). La génétique en recherche biomédicale. 18e Forum International Science et Société ACFAS. Sherbrooke, Canada
- *Lacarrière C. and Jean S. (2017). Rôle et régulation de la pseudophosphatase MTMR13/SBF dans l’homéostasie intestinale. 86e congrès de l’ACFAS. Montreal, Canada
- *Lacarrière C. and Jean S. (2017). Rôle et régulation de la pseudophosphatase MTMR13/SBF dans l’homéostasie intestinale. Club de Recherche Clinique du Québec. Orford, Canada
- *Normandin C. and Jean S. (2017). TBC1D25, TBC1D13, TBCK : régulateur ou effecteur de Rab21. 86e congrès de l’ACFAS. Montreal, Canada
- *Normandin C. and Jean S. (2017). TBC1D25, TBC1D13, TBCK : régulateur ou effecteur de Rab21. Club de Recherche Clinique du Québec. Orford, Canada
- Jean S., Leung G. (2017). The fly and zebrafish as models to study GI tract disorders. Canadian Digestive Disease Week 2017. Banff, Canada
- Jean S. (2016). Endosomal regulation of autophagy. McGill University, Department of Biology. Guest speaker invitation for their seminar series. Montreal, Canada
- Jean S. (2016). Identification de nouveaux régulateurs du flux autophagique et rôles dans le cancer. Cancer research axis retreat. Canada
- Jean S. (2015). Nouvelles fonctions du système endosomal dans l'autophagie et le cancer colorectal. Centre de recherche du CHUS. Guest speaker invitation for seminar series. Sherbrooke, Canada
- Jean S., Cox S. and Kiger A. (2015). Rab21 and Sbf regulate autophagosome-lysosome fusion. CanFly XIII 2015. Montréal, Canada
- J. Groulx, S. Jean, N. Fujita, M. Velichkova, P. Kadandale, S. Cox, A.A. Kiger. (2015). Roles for Class II PI3K and Mtm in autophagy. American Society of Cell Biology 2015 Meeting. San Diego, United States of America
- Jean S., Cox S., Nassari S., Kiger A. (2014). Régulation endosomale de l’autophagie. Signalisation Québec 2014. Bécancour, Canada
- Jean S., Cox S., Kiger A. (2014). Starvation-induced MTMR13 and Rab21 activity promotes VAMP8 autophagosome-lysosome fusion. 9th EMBO/Workshop, Protein and lipid function in secretion and endocytosis. Goldegg am See, Austria
- Jean S., Cox S., Kiger A. (2014). Starvation-induced MTMR13 and Rab21 activity promotes VAMP8 autophagosome-lysosome fusion. 2014 Annual drosophila research conference. San Diego, United States of America
- Jean S., Cox S., Kiger A. (2013). Rab21 and Sbf are required for autophagic flux. Autophagy in cell stress, SDCSB symposium. San Diego, United States of America
- Jean S., Cox S., Kiger A. (2012). Coordination of PI(3)P and Rab21 in cell remodeling. Phosphoinositide Biology, Signaling and Cancer Symposium. Montréal, Canada
- Jean S., Cox S., Kiger A. (2012). Coordination of PI(3)P and Rab21 in cell remodeling and autophagy. Centre de Recherche en Cancérologie de l’Université Laval. Québec, Canada
- Jean S., Cox S., Kiger A. (2012). Coordination of PI(3)P and Rab21 in cell remodeling and autophagy. Département d’anatomie-biologie cellulaire Université Sherbrooke. Sherbrooke, Canada
- Jean S., Cox S., Kiger A. (2012). Coordination of PI(3)P and Rab21 in membrane trafficking. Gordon Research Conference. Andover, United States of America
- Jean S., Cox S., Kiger A. (2012). Coordination of PI(3)P and Rab21 in membrane trafficking. Gordon Research Seminar. Andover, United States of America
- Velichkova M., Kadandale P., Jean S., Cox S., Kiger A. (2012). Not all PI(3)P is created equal: Roles of class II PI3-kinase in metazoan autophagy. Gordon Research Conference. Ventura, United States of America
- Velichkova M., Kadandale P., Jean S., Kiger A. (2011). Class II PI3-Kinase and Regulators of Membrane Trafficking Coordinately Regulate Autophagy. Autophagy Keystone Symposia. Whistler, Canada
- Jean S., Ribeiro I., Velichkova M., Kadandale P., Kiger A. (2011). Coordinated PI3KC2/Mtm Phosphoinositide Regulation and Rab activity in Membrane Trafficking and Disease. Inositide Signaling in Pharmacology and Disease Keystone Symposia. Boulder, United States of America
- Jean S., Cox S., Kiger A. (2011). Coordination of phosphoinositide and Rab GTPase regulation and functions. Goethe Universität Frankfurt. Frankfurt, Germany
- Jean S, Cox S, Kiger A. (2011). Sbf, an MTM pseudophosphatase, coregulates PI(3)P homeostasis and Rab21 activity with essential requirements for hemocyte shape. International Drosophila Research conference. San Diego, United States of America
- Jean S., Cox S., Robinson F., Kiger A. (2011). Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. UCSD biology retreat. Lake Arrowhead, United States of America
- Jean S., Cox S., Robinson F., Kiger A. (2010). Sbf, an Mtm pseudophosphatase, more than meets the eye!. UCSD biology retreat. Lake Arrowhead, United States of America
- Jean S., Velichkova M., Juan J. and Kiger A. (2009). The myotubularin pseudophosphatase, Sbf, scaffolds a protein complex comprising Mtm, a catalytically active myotubularin phosphatase, and the class II PI3K, PI3K68D, to regulate PI(3)P dynamic. American Society for Cell Biology Meeting. San Diego, United States of America